synthesis and in-vitro anti-bacterial activity of new thiazolidin-4-one derivatives
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منابع مشابه
Synthesis and in vitro Anti-Bacterial Activity of 2-(5-Nitro-2-heteroaryl)-1,3,4-Thiadiazole Derivatives
A new series of 2-(5-nitro-2-heteroaryl)-1,3,4-thiadiazole derivatives, including nitro furan, nitro thiophene and nitro imidazole, were synthesized and screened in vitro for their inhibitory activity against eight bacterial strains. The results showed that most of the synthesized compounds were active against Gram-positive bacteria, determined by MIC method. Among them, compounds <str...
متن کاملSynthesis, characterization and antioxidant activity of some new thiazolidin-4-one derivatives.
AIM To design new thiazolidin-4-ones derivatives and to evaluate their potential antioxidant effects using in vitro methods. MATERIAL AND METHODS New ethyl esters of the 2-(R-phenyl)-4-oxo-thiazolidin-3-yl propionic acid were synthesized using "one step reaction" between different aromatic aldehydes, thioglycolic acid and beta-alanine ethyl ester hydrochloride. The antioxidant potential of th...
متن کاملDevelopment and optimization of the synthesis of new thiazolidin-4-one derivatives of ibuprofen.
UNLABELLED Ibuprofen, an important nonsteroidal anti-inflammatory agent, is one of the most prescribed drugs for the treatment of pain and inflammation from various rheumatic diseases, but some side effects can occur on long-term use. AIM The method for synthesis optimization of new derivatives of Ibuprofen with thiazolidin-4-one moiety, with improved pharmacological and toxicological profile...
متن کاملThe synthesis and the biological evaluation of new thiazolidin-4-one derivatives containing a xanthine moiety.
Starting from theophylline (1,3-dimethylxanthine) new thiazolidin-4-one derivatives 7a₁₋₇, 7b₁₋₇ have been synthesized as potential antidiabetic drugs. The structure of the new derivatives was confirmed using spectral methods (FT-IR, ¹H-NMR, ¹³C-NMR). The in vitro antioxidant potential of the synthesized compounds was evaluated according to the ferric reducing power, the total antioxidant activ...
متن کاملSynthesis and Antimicrobial Activity of New Schiff Base Containing Thiazolidin -4-One and their Spectral Characterization
Heterocyclic Compounds having a valuable place in a Heterocyclic Chemistry and Heterocyclic Compounds having a excellent properties such as drugs, dyes etc, This compounds are showing anti microbial, anti fungal, anti bacterial, anti inflammatory,anti diabetic, anti hypertensive etc. properties. In present investigation, we have prepared 2-{4-[2-{3,5bis-(4-methoxyphenyl)-4,5-dihydro-pyrazol-1-y...
متن کاملSynthesis and anti-tubercular activity of 6-Substtitutedaryl-4-Arylidene-4,5-dihydropyridazin-3(2H)-one derivatives against Mycobacterium tuberculosis
Pyridazine plays a significant role in pharmaceuticals particularly in the field of medicinal chemistry. Several 4-substituted-benzylidene-6-substituted-phenyl-dihydro-pyridazin-3(2H)-one derivatives (3a-q) were synthesized and evaluated for their antimicrobial activities with an aim to obtain promising antitubercular agents. In the first step, 6-aryl-tetrahydro-pyridazin-3-ones (2) were prepar...
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عنوان ژورنال:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
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